If this is the case, make a new profile and set (NOT DPI) but what logitech calls "Support Rate" to the lowest setting 125.
(if you are lucky) you have a logitech newer model mouse that supports logitech g hub. In order to fix this get an older mouse that doesn't poll so quickly Newer mouses (mice whatever) have polling times that are far too high for the game to handle and it will cause almost unplayable jitter/lag in the movement of the God Hand. Install all THREE patches in order for optimal performance on windows 10. This download will work, but for me it took not just the 1.1 and 1.2 patches available on this site but also and additional 1.42 patch I found online (it is fan created so tread lightly I take no responsibility blah blah blah). My previous comment had some typos and more I could say so here is the correction (with original text below):
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